Human Aquaporin 0 (MIP) activation kit by CRISPRa

SKU GA102911

MIP CRISPRa kit - CRISPR gene activation of human major intrinsic protein of lens fiber

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: MIP
• Locus ID: 4284
• Components:

  GA102911G1, Aquaporin 0 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102911G2, Aquaporin 0 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102911G3, Aquaporin 0 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_012064
• UniProt ID: P30301
• Synonyms: AQP0; CTRCT15; LIM1; MIP26; MP26
• Summary: Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008]