Human Manic Fringe (MFNG) activation kit by CRISPRa

SKU GA102891

MFNG CRISPRa kit - CRISPR gene activation of human MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: MFNG
• Locus ID: 4242
• Components:

  GA102891G1, Manic Fringe gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102891G2, Manic Fringe gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102891G3, Manic Fringe gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001166343, NM_002405, NR_029413
• UniProt ID: O00587
• Summary: This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the LFNG (GeneID: 3955) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encoded by this gene may control Notch signaling in claudin-low breast cancer. [provided by RefSeq, May 2018]