Human Cytokeratin 19 (KRT19) activation kit by CRISPRa

SKU GA102628

KRT19 CRISPRa kit - CRISPR gene activation of human keratin 19

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: KRT19
• Locus ID: 3880
• Components:

  GA102628G1, Cytokeratin 19 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102628G2, Cytokeratin 19 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102628G3, Cytokeratin 19 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_002276
• UniProt ID: P08727
• Synonyms: CK19; K1CS; K19
• Summary: The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]