Human Iduronate 2 sulfatase (IDS) activation kit by CRISPRa

SKU GA102316

IDS CRISPRa kit - CRISPR gene activation of human iduronate 2-sulfatase

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: IDS
• Locus ID: 3423
• Components:

  GA102316G1, Iduronate 2 sulfatase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102316G2, Iduronate 2 sulfatase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102316G3, Iduronate 2 sulfatase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000202, NM_001166550, NM_006123, NR_104128
• UniProt ID: P22304
• Synonyms: MPS2; SIDS
• Summary: This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]