Human HOX11 (TLX1) activation kit by CRISPRa

SKU GA102181

TLX1 CRISPRa kit - CRISPR gene activation of human T cell leukemia homeobox 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: TLX1
• Locus ID: 3195
• Components:

  GA102181G1, HOX11 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102181G2, HOX11 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102181G3, HOX11 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001195517, NM_005521
• UniProt ID: P31314
• Synonyms: HOX11; TCL3
• Summary: This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]