Human Uroguanylin (GUCA2B) activation kit by CRISPRa

SKU GA102022

GUCA2B CRISPRa kit - CRISPR gene activation of human guanylate cyclase activator 2B

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: GUCA2B
• Locus ID: 2981
• Components:

  GA102022G1, Uroguanylin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102022G2, Uroguanylin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102022G3, Uroguanylin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_007102
• UniProt ID: Q16661
• Synonyms: GCAP-II; UGN
• Summary: This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. [provided by RefSeq, Nov 2015]