Human GRIA1 activation kit by CRISPRa

SKU GA101946

GRIA1 CRISPRa kit - CRISPR gene activation of human glutamate ionotropic receptor AMPA type subunit 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: GRIA1
• Locus ID: 2890
• Components:

  GA101946G1, GRIA1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101946G2, GRIA1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101946G3, GRIA1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000827, NM_001114183, NM_001258019, NM_001258020, NM_001258021, NM_001258022, NM_001258023, NR_047578, NM_001364165, NM_001364166, NM_001364167, NR_157093
• UniProt ID: P42261
• Synonyms: GluA1; GLUH1; GLUR1; GLURA; HBGR1
• Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]