Human GABA A Receptor gamma 2 (GABRG2) activation kit by CRISPRa

SKU GA101709

GABRG2 CRISPRa kit - CRISPR gene activation of human gamma-aminobutyric acid type A receptor gamma2 subunit

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: GABRG2
• Locus ID: 2566
• Components:

  GA101709G1, GABA A Receptor gamma 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101709G2, GABA A Receptor gamma 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101709G3, GABA A Receptor gamma 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000816, NM_198903, NM_198904
• UniProt ID: P18507
• Synonyms: CAE2; ECA2; GEFSP3
• Summary: This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]