Human Fos B (FOSB) activation kit by CRISPRa

SKU GA101649

FOSB CRISPRa kit - CRISPR gene activation of human FosB proto-oncogene, AP-1 transcription factor subunit

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: FOSB
• Locus ID: 2354
• Components:

  GA101649G1, Fos B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101649G2, Fos B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101649G3, Fos B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001114171, NM_006732
• UniProt ID: P53539
• Synonyms: AP-1; G0S3; GOS3; GOSB
• Summary: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]