Human Filaggrin (FLG) activation kit by CRISPRa

SKU GA101621

FLG CRISPRa kit - CRISPR gene activation of human filaggrin

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: FLG
• Locus ID: 2312
• Components:

  GA101621G1, Filaggrin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101621G2, Filaggrin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101621G3, Filaggrin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_002016
• UniProt ID: P20930
• Synonyms: ATOD2
• Summary: The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]