Human Endothelin 1 (EDN1) activation kit by CRISPRa

SKU GA101327

EDN1 CRISPRa kit - CRISPR gene activation of human endothelin 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: EDN1
• Locus ID: 1906
• Components:

  GA101327G1, Endothelin 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101327G2, Endothelin 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101327G3, Endothelin 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001168319, NM_001955
• UniProt ID: P05305
• Synonyms: ARCND3; ET1; HDLCQ7; PPET1; QME
• Summary: This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]