Human Desmoglein 1 (DSG1) activation kit by CRISPRa

SKU GA101279

DSG1 CRISPRa kit - CRISPR gene activation of human desmoglein 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: DSG1
• Locus ID: 1828
• Components:

  GA101279G1, Desmoglein 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101279G2, Desmoglein 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101279G3, Desmoglein 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001942
• UniProt ID: Q02413
• Synonyms: CDHF4; DG1; DSG; EPKHE; EPKHIA; PPKS1; SPPK1
• Summary: This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]