Human Dopamine Receptor D4 (DRD4) activation kit by CRISPRa

SKU GA101268

DRD4 CRISPRa kit - CRISPR gene activation of human dopamine receptor D4

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: DRD4
• Locus ID: 1815
• Components:

  GA101268G1, Dopamine Receptor D4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101268G2, Dopamine Receptor D4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101268G3, Dopamine Receptor D4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000797
• UniProt ID: P21917
• Synonyms: D4DR
• Summary: This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]