Human DNase gamma (DNASE1L3) activation kit by CRISPRa

SKU GA101235

DNASE1L3 CRISPRa kit - CRISPR gene activation of human deoxyribonuclease 1 like 3

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: DNASE1L3
• Locus ID: 1776
• Components:

  GA101235G1, DNase gamma gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101235G2, DNase gamma gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101235G3, DNase gamma gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001256560, NM_004944
• UniProt ID: Q13609
• Synonyms: DHP2; DNAS1L3; LSD; SLEB16
• Summary: This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]