Human beta Defensin 1 (DEFB1) activation kit by CRISPRa

SKU GA101182

DEFB1 CRISPRa kit - CRISPR gene activation of human defensin beta 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: DEFB1
• Locus ID: 1672
• Components:

  GA101182G1, beta Defensin 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101182G2, beta Defensin 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101182G3, beta Defensin 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_005218
• UniProt ID: P60022
• Synonyms: BD1; DEFB-1; DEFB101; HBD1
• Summary: Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]