Human Corticotropin Releasing Factor Receptor 2 (CRHR2) activation kit by CRISPRa

SKU GA100980

CRHR2 CRISPRa kit - CRISPR gene activation of human corticotropin releasing hormone receptor 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: CRHR2
• Locus ID: 1395
• Components:

  GA100980G1, Corticotropin Releasing Factor Receptor 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100980G2, Corticotropin Releasing Factor Receptor 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100980G3, Corticotropin Releasing Factor Receptor 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001202475, NM_001202481, NM_001202482, NM_001202483, NM_001883
• UniProt ID: Q13324
• Synonyms: CRF-RB; CRF2; CRFR2; HM-CRF
• Summary: The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]