Human Carbonic Anhydrase IV (CA4) activation kit by CRISPRa

SKU GA100530

CA4 CRISPRa kit - CRISPR gene activation of human carbonic anhydrase 4

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: CA4
• Locus ID: 762
• Components:

  GA100530G1, Carbonic Anhydrase IV gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100530G2, Carbonic Anhydrase IV gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100530G3, Carbonic Anhydrase IV gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000717, NR_137422
• UniProt ID: P22748
• Synonyms: CAIV; Car4; RP17
• Summary: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. [provided by RefSeq, Jul 2008]