Human APXL (SHROOM2) activation kit by CRISPRa

SKU GA100254

SHROOM2 CRISPRa kit - CRISPR gene activation of human shroom family member 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SHROOM2
• Locus ID: 357
• Components:

  GA100254G1, APXL gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100254G2, APXL gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100254G3, APXL gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001649, NM_001320663, NM_001320664
• UniProt ID: Q13796
• Synonyms: APXL; HSAPXL
• Summary: This gene represents the human homolog of Xenopus laevis apical protein (APX) gene, which is implicated in amiloride-sensitive sodium channel activity. It is expressed in endothelial cells and facilitates the formation of a contractile network within endothelial cells. Depletion of this gene results in an increase in endothelial sprouting, migration, and angiogenesis. This gene is highly expressed in the retina, and is a strong candidate for ocular albinism type 1 syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]