Human Apolipoprotein CI (APOC1) activation kit by CRISPRa

SKU GA100241

APOC1 CRISPRa kit - CRISPR gene activation of human apolipoprotein C1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: APOC1
• Locus ID: 341
• Components:

  GA100241G1, Apolipoprotein CI gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100241G2, Apolipoprotein CI gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100241G3, Apolipoprotein CI gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001321065, NM_001321066, NM_001645
• UniProt ID: P02654
• Synonyms: Apo-CI; apo-CIB; ApoC-I; apoC-IB
• Summary: This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]