Human Adenylosuccinate Lyase (ADSL) activation kit by CRISPRa

SKU GA100111

ADSL CRISPRa kit - CRISPR gene activation of human adenylosuccinate lyase

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ADSL
• Locus ID: 158
• Components:

  GA100111G1, Adenylosuccinate Lyase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100111G2, Adenylosuccinate Lyase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100111G3, Adenylosuccinate Lyase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000026, NM_001123378, NM_001317923, NR_134256, NM_001363840
• UniProt ID: P30566
• Synonyms: AMPS; ASASE; ASL
• Summary: The protein encoded by this gene belongs to the lyase 1 family. It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to adenosine monophosphate (AMP). Mutations in this gene are associated with adenylosuccinase deficiency (ADSLD), a disorder marked with psychomotor retardation, epilepsy or autistic features. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]