Human alpha smooth muscle Actin (ACTA2) activation kit by CRISPRa

SKU GA100046

ACTA2 CRISPRa kit - CRISPR gene activation of human actin alpha 2, smooth muscle

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ACTA2
• Locus ID: 59
• Components:

  GA100046G1, alpha smooth muscle Actin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100046G2, alpha smooth muscle Actin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100046G3, alpha smooth muscle Actin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001141945, NM_001320855, NM_001613
• UniProt ID: P62736
• Synonyms: AAT6; ACTSA; MYMY5
• Summary: This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome. [provided by RefSeq, Sep 2017]