Human Aconitase 2 (ACO2) activation kit by CRISPRa

SKU GA100038

ACO2 CRISPRa kit - CRISPR gene activation of human aconitase 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ACO2
• Locus ID: 50
• Components:

  GA100038G1, Aconitase 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100038G2, Aconitase 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100038G3, Aconitase 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001098
• UniProt ID: Q99798
• Synonyms: ACONM; HEL-S-284; ICRD; OCA8; OPA9
• Summary: The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]