PGPEP1 (NM_017712) Human Tagged ORF Clone Lentiviral Particle

SKU RC214837L3V

Lenti ORF particles, PGPEP1 (Myc-DDK tagged) - Human pyroglutamyl-peptidase I (PGPEP1), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: PGPEP1
• Synonyms: PAP-I; Pcp; PGI; PGP; PGP-I; PGPI
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC214837).
• ACCN: NM_017712
• ORF Size: 627 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_017712.1
• RefSeq Size: 2239 bp
• RefSeq ORF: 630 bp
• Locus ID: 54858
• UniProt ID: Q9NXJ5
• Cytogenetics: 19p13.11
• Protein Families: Druggable Genome, Protease
• MW: 23 kDa
• Summary: The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]