HTRA3 (NM_053044) Human Tagged ORF Clone Lentiviral Particle

SKU RC207810L1V

Lenti ORF particles, HTRA3 (Myc-DDK tagged) - Human HtrA serine peptidase 3 (HTRA3), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: HTRA3
• Synonyms: Prsp; Tasp
• Vector: pLenti-C-Myc-DDK
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC207810).
• ACCN: NM_053044
• ORF Size: 1359 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_053044.2
• RefSeq Size: 2585 bp
• RefSeq ORF: 1362 bp
• Locus ID: 94031
• UniProt ID: P83110
• Cytogenetics: 4p16.1
• Domains: IB, kazal, PDZ, Tryp_SPc
• Protein Families: Druggable Genome, Protease, Secreted Protein
• MW: 48.4 kDa
• Summary: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724).[UniProtKB/Swiss-Prot Function]