NKX2.8 (NKX2-8) (NM_014360) Human Tagged ORF Clone Lentiviral Particle

SKU RC207752L3V

Lenti ORF particles, NKX2 (Myc-DDK tagged) - Human NK2 homeobox 8 (NKX2-8), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: NKX2.8
• Synonyms: Nkx2-9; NKX2.8; NKX2H
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC207752).
• ACCN: NM_014360
• ORF Size: 717 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_014360.2
• RefSeq Size: 1857 bp
• RefSeq ORF: 720 bp
• Locus ID: 26257
• UniProt ID: O15522
• Cytogenetics: 14q13.3
• Protein Families: Druggable Genome, Transcription Factors
• MW: 25.9 kDa
• Summary: The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects. [provided by RefSeq, Dec 2015]