FRS2 (NM_006654) Human Tagged ORF Clone Lentiviral Particle

SKU RC205842L1V

Lenti ORF particles, FRS2 (Myc-DDK tagged) - Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: FRS2
• Synonyms: FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1
• Vector: pLenti-C-Myc-DDK
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC205842).
• ACCN: NM_006654
• ORF Size: 1536 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_006654.3, NP_006645.2
• RefSeq Size: 6883 bp
• RefSeq ORF: 1527 bp
• Locus ID: 10818
• UniProt ID: Q8WU20
• Cytogenetics: 12q15
• Domains: IRS
• Protein Families: Druggable Genome
• Protein Pathways: Neurotrophin signaling pathway
• MW: 57.5 kDa
• Summary: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.[UniProtKB/Swiss-Prot Function]