FRS2 (NM_006654) Human Untagged Clone

SKU SC115938

FRS2 (untagged)-Human fibroblast growth factor receptor substrate 2 (FRS2), transcript variant 1

Product Data

• Type: Human Untagged Clone
• Target Symbol: FRS2
• Synonyms: FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC115938 sequence for NM_006654 edited (data generated by NextGen Sequencing); ATGGGTAGCTGTTGTAGCTGTCCAGATAAAGACACTGTCCCAGATAACCATCGGAACAAG; TTTAAGGTCATTAATGTGGATGATGATGGGAATGAGTTAGGTTCTGGCATAATGGAACTT; ACAGACACAGAACTGATTTTATACACCCGCAAACGTGACTCAGTAAAATGGCACTACCTC; TGCCTGCGACGCTATGGCTATGACTCGAATCTCTTTTCTTTTGAAAGTGGTCGAAGGTGT; CAAACTGGACAAGGAATCTTTGCCTTTAAGTGTGCCCGTGCAGAAGAATTATTTAACATG; TTGCAAGAGATTATGCAAAATAATAGTATAAATGTGGTGGAAGAGCCAGTTGTAGAAAGA; AATAATCATCAGACAGAATTGGAAGTCCCTAGAACACCTCGAACACCTACAACTCCAGGA; TTTGCTGCTCAGAACTTACCTAATGGATATCCCCGATATCCCTCATTTGGAGATGCTTCA; TCCCATCCGTCAAGCAGACATCCTTCTGTGGGAAGTGCTCGCCTGCCTTCAGTAGGGGAA; GAATCTACACATCCTTTGCTTGTGGCTGAGGAACAAGTACATACCTATGTCAACACTACA; GGTGTGCAAGAAGAGCGGAAAAACCGCACAAGTGTGCATGTTCCATTGGAGGCGAGGGTT; TCTAACGCTGAAAGCAGCACACCAAAAGAAGAACCAAGTAGTATTGAGGACAGGGATCCT; CAGATTCTTCTTGAACCTGAAGGAGTCAAATTTGTTTTAGGGCCAACCCCTGTTCAAAAG; CAGTTAATGGAAAAAGAGAAACTGGAGCAACTTGGAAGAGATCAAGTTAGTGGAAGTGGA; GCAAATAACACAGAATGGGACACTGGCTATGACAGTGATGAACGAAGAGATGCACCCTCT; GTTAACAAACTGGTGTATGAAAATATAAATGGGCTATCTATCCCTAGTGCCTCAGGGGTC; AGGAGAGGTCGTCTGACATCCACCAGTACCTCAGATACCCAGAATATCAACAACTCAGCT; CAGAGAAGAACTGCATTATTAAACTATGAAAATCTACCATCTTTGCCTCCTGTTTGGGAA; GCCCGCAAGCTAAGTAGGGATGAAGATGACAATTTAGGACCAAAGACCCCATCTCTAAAT; GGCTACCATAATAATCTAGATCCAATGCATAACTATGTAAATACAGAGAATGTAACAGTG; CCAGCAAGTGCTCACAAAATAGAATATTCAAGGCGTCGGGACTGTACACCAACAGTCTTT; AACTTTGATATCAGACGCCCAAGTTTAGAACACAGGCAGCTTAATTACATACAGGTTGAC; TTGGAAGGTGGCAGTGACTCTGACAACCCTCAGACTCCAAAAACGCCTACAACTCCCCTT; CCACAAACCCCTACCAGGCGCACAGAGCTGTATGCCGTGATAGACATCGAGAGAACTGCT; GCTATGTCAAATTTGCAGAAAGCACTGCCACGAGATGATGGTACATCTAGGAAAACTAGA; CACAATAGTACTGATCTGCCCATGTGA; ; Clone variation with respect to NM_006654.3;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006654 unedited; TTCGGCACGAGGGCTGCCAGAAAGCTCATAAGGAATATTATTCTTTAGAAATGAGAAATT; CTCAATGTTTTTCTTCTGTTTTTAGGTTAAATCAGCAAACAAAGAAAACATGGTATTTTG; AAATATGATTAAACTCCTGATGCTGCAGCAGAGGCTAAGAATATTAATGGCCAGATCTAG; TGCACACATGGTCTTCTGAAGAAGCCATGGGTAGCTGTTGTAGCTGTCCAGATAAAGACA; CTGTCCCAGATAACCATCGGAACAAGTTTAAGGTCATTAATGTGGATGATGATGGGAATG; AGTTAGGTTCTGGCATAATGGAACTTACAGACACAGAACTGATTTTATACACCCGCAAAC; GTGACTCAGTAAAATGGCACTACCTCTGCCTGCGACGCTATGGCTATGACTCGAATCTCT; TTTCTTTTGAAAGTGGTCGAAGGTGTCAAACTGGACAAGGAATCTTTGCCTTTAAGTGTG; CCCGTGCAGAAGAATTATTTAACATGTTGCAAGAGATTATGCAAAATAATAGTATAAATG; TGGTGGAAGAGCCAGTTGTAGAAAGAAATAATCATCAGACAGAATTGGAAGTCCCTAGAA; CACCTCGAACACCTACAACTCCAGGATTTGCTGCTCAGAACTTACCTAATGGATATCCCC; GATATCCCTCATTTGGAGATGCTTCATCCCATCCGTCAAGCAGACATCCTTCTGTNGGGA; AGTGCTCGCCTGCCTTCAGTAGGGGAAGAATCTACACATNCTTTGCTTGTGGCTGAGGAC; A;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_006654 unedited; GGATATTTGGGGTTTTTTTACCCATTTTATGTTTTTATCCACACACACTACACATTGTAC; AAAACATTTGGGCCTTGGGGGTTAGGGAAAAACCCGGGGGGAATTGGGAAAACTTTTCTC; TGGAAAAACCTTTCCTTGCAGCATAAGATATGGCGGCACATTGTTGGGAAATATGAAAAC; TTTAGGCCCCCGCCCCATTTGTAAAAAAACATTTTTGGGGCCCCTTTTTTTTGGCGGGGC; CGCGGTTTTGGGGAGGGGGAGGAGATAAACCCTACCTTGACTTGTCCTATTAAAAACCTT; GAACCCTGGAGAGAGTCAACATTATTGTCTGTAAAAACAAACTTTGCTCGCCAAATTTTC; CTAACTCCCAAATTTGAGGTATTCGGGAAATTCTGGGAAGTGAAAAGCTTTTTGCTGAAT; CTTAAAGAGTAAAGTGCATACCTCATCACTCCACAGAAACTTTAAATAAAAGGAAATTTT; TGCCAATCTTCCCGGAGGGGGGGAAGGCACCATATTTTCATTTTTAAAAAAAGATGACAC; TGGGAAATAAAACACACTAACAAAAACCCTTGTAATACCAATATCGGTTTCCAACCCTAG; CATGGGATAGATGCTGATAAGAATTGTCTGGATAAAACAATATCTTTTTGGAGGGAAACT; TCACCACGATTAAATTTCCAAACCAGAACGAGGATCACATGGTCAACAAACAAATCTCCT; AAAATTTATTCTGCCTCGGAAAACTTAAATTTTTGGCCCACATTTTTGGCTAATAAAAAA; AACCTTTTATTTTGAAAAGCCCCCCGGAAGAAGGCCCATCCTTCCGGGGACCAACTTTTG; GGCCATTAAAAAAATTTGCAAAGAACCTTTTTTTTTTAAAAACCCCTTTTTTATAAGGAA; CCCTTTGGTTTTCTAAAATTTTTT;
• Restriction Sites: NotI-NotI
• ACCN: NM_006654
• Insert Size: 5200 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_006654.2, NP_006645.2
• RefSeq Size: 1840 bp
• RefSeq ORF: 1539 bp
• Locus ID: 10818
• UniProt ID: Q8WU20
• Cytogenetics: 12q15
• Domains: IRS
• Protein Families: Druggable Genome
• Protein Pathways: Neurotrophin signaling pathway
• Summary: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.[UniProtKB/Swiss-Prot Function]; Transcript Variant: This variant (1) lacks an exon in the 5' UTR, compared to variant 3. All variants encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.