TDO2 (NM_005651) Human Tagged ORF Clone Lentiviral Particle

SKU RC202777L3V

Lenti ORF particles, TDO2 (Myc-DDK tagged) - Human tryptophan 2,3-dioxygenase (TDO2), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: TDO2
• Synonyms: HYPTRP; TDO; TO; TPH2; TRPO
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC202777).
• ACCN: NM_005651
• ORF Size: 1218 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_005651.1
• RefSeq Size: 1703 bp
• RefSeq ORF: 1221 bp
• Locus ID: 6999
• UniProt ID: P48775
• Cytogenetics: 4q32.1
• Domains: Trp_dioxygenase
• Protein Pathways: Metabolic pathways, Tryptophan metabolism
• MW: 47.9 kDa
• Summary: This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]