DAB2 (NM_001343) Human Tagged ORF Clone Lentiviral Particle

SKU RC200481L1V

Lenti ORF particles, DAB2 (Myc-DDK tagged) - Human disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: DAB2
• Synonyms: DOC-2; DOC2
• Vector: pLenti-C-Myc-DDK
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC200481).
• ACCN: NM_001343
• ORF Size: 2310 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_001343.1
• RefSeq Size: 3268 bp
• RefSeq ORF: 2313 bp
• Locus ID: 1601
• UniProt ID: P98082
• Cytogenetics: 5p13.1
• Domains: PID
• Protein Families: Druggable Genome
• Protein Pathways: Endocytosis
• MW: 82.3 kDa
• Summary: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]