B Raf (BRAF) Mouse Monoclonal Antibody [Clone ID: OTI1E2]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI1E2 |
|---|---|
| Application | FC, IF, IP, WB |
| Recommended Dilution | WB 1:2000, IF 1:100, Flow 1:100 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human BRAF (NP_004324) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 84.4 kDa |
| Gene Name | B-Raf proto-oncogene, serine/threonine kinase |
| Database Link | |
| Background | This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. |
| Synonyms | B-raf; B-RAF1; BRAF1; NS7; RAFB1 |
| Reference Data | |
| Protein Categories | ADC Targets, Cancer: Endocrine, Cancer: Gastrointestinal, Cancer: Haematopoietic and Lymphoid, Cancer: Lung, Cancer: Skin, Cytokines, Enzyme: Kinases, Growth Factors, Intracellular Proteins |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | Acute myeloid leukemia, Bladder cancer, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Focal adhesion, Glioma, Insulin signaling pathway, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanoma, mTOR signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, Thyroid cancer, Vascular smooth muscle contraction |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI1E2" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF500845 | Carrier-free (BSA/glycerol-free) BRAF mouse monoclonal antibody, clone OTI1E2 (formerly 1E2) | 100 ug |
$620.00
|
|
| TA500845AM | Anti-BRAF mouse monoclonal antibody, clone OTI1E2 (formerly 1E2), Biotinylated | 100 ul |
$509.00
|
|
| TA500845BM | Anti-BRAF mouse monoclonal antibody, clone OTI1E2 (formerly 1E2), HRP conjugated | 100 ul |
$509.00
|
|
| TA500845S | Anti-BRAF mouse monoclonal antibody, clone OTI1E2 (formerly 1E2) | 30 ul |
$200.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
