TLR4 Human shRNA Plasmid Kit (Locus ID 7099)

SKU TG320555

TLR4 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 7099
• Synonyms: ARMD10; CD284; TLR-4; TOLL
• Vector: pGFP-V-RS
• E. coli Selection: Kan
• Format: Retroviral plasmids
• Components: TLR4 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 7099). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
• RefSeq: NM_003266, NM_138554, NM_138556, NM_138557, NR_024168, NR_024169, NM_138554.1, NM_138554.2, NM_138554.3, NM_138554.4, NM_138557.1, NM_138557.2, NM_003266.1, NM_003266.2, NM_003266.3, NM_138556.1, BC025294, BC117422, BC143841, NM_003266.4, NM_138557.3, NM_138554.5
• UniProt ID: O00206
• Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient