PD-L1 (CD274) Human Recombinant Protein
Specifications
Product Data | |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence |
PD-L1(Phe19-Arg328)+mFc(Pro99-Lys330)+6×His tag
|
Tag | C-Mouse Fc and 6×His |
Predicted MW | 52.3 kDa |
Purity | > 95% |
Buffer | Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose is added as protectants before lyophilization |
Reconstitution | Reconstitute with deionized water |
Preparation | Affinity purification |
Applications | ELISA |
Storage | Store the lyophilized protein at -20°C. After reconstitution, store the protein at -80°C for 12 months. Avoid repeated freezing and thawing. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 29126 |
UniProt ID | Q9NZQ7 |
Summary | This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. |
Documents
FAQs |
SDS |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC415473 | CD274 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 134.00 |
|
LY415473 | Transient overexpression lysate of PD-L1 / CD274 molecule (PD-L1 / CD274) |
USD 436.00 |
|
TP700200 | Purified recombinant protein of Homo sapiens programmed cell death 1 ligand 1(PD-L1/CD274), transcript variant 1, residue 19-239aa, with C-terminal DDK/His tag, expressed in HEK293 cells. |
USD 867.00 |
|
TP700201 | Purified recombinant protein of Homo sapiens programmed cell death 1 ligand 1 (PD-L1/CD274), residues 19-239aa, with C-terminal Fc tag, expressed in HEK293 cells. |
USD 867.00 |
|
TP710226 | Purified recombinant protein of Human CD274 molecule (CD274), residues 19-290aa, with C-terminal DDK tag, expressed in sf9 insect cells |
USD 515.00 |
|
TP710227 | Purified recombinant protein of Homo sapiens programmed cell death 1 ligand 1(PD-L1/CD274), transcript variant 1, extracellular domain residue (19-238aa) with C-terminal DDK tag, expressed and secreted from insect sf9 cells, 20ug |
USD 515.00 |
|
TP720630 | Purified recombinant protein of Human PD-L1 / CD274 molecule (PD-L1 / CD274) |
USD 330.00 |
|
TP721254 | Human PD-L1 Protein (C-His) |
USD 258.00 |
|
TP721255 | Human PD-L1 Protein (C-His-Avi) |
USD 258.00 |
|
TP721256 | Biotinylated Human PD-L1 Protein (C-His-Avi) |
USD 366.00 |
|
TP721257 | PE Conjugated Human PD-L1 Protein (C-His) |
USD 366.00 |
|
TP721258 | APC Conjugated Human PD-L1 Protein (C-His) |
USD 366.00 |
|
TP721259 | Human PD-L1 Protein (C-Fc) |
USD 258.00 |
|
TP721260 | Human PD-L1 Protein (C-Fc-Avi) |
USD 258.00 |
|
TP721261 | Biotinylated Human PD-L1 Protein (C-Fc-Avi) |
USD 366.00 |
|
TP721262 | PE Conjugated Human PD-L1 Protein (C-Fc) |
USD 366.00 |
|
TP721263 | APC Conjugated Human PD-L1 Protein (C-Fc) |
USD 366.00 |
|
TP724015 | Human PD-L1 Protein, His tag |
USD 520.00 |
|
TP762432 | Purified recombinant protein of Human PD-L1 / CD274 molecule (PD-L1 / CD274), Trp13-Thr239, with N-terminal His tag, expressed in E.coli, 50ug |
USD 226.00 |
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