HEPC (HAMP) (NM_021175) Human Recombinant Protein

SKU TP721154

Purified recombinant protein of Human hepcidin antimicrobial peptide (HAMP)

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Asp60-Thr84
• Tag: N-GST
• Predicted MW: 2.92 kDa
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Supplied as a 0.2 um filtered solution of PBS, 50% Glycerol, pH 7.4.
• Endotoxin: Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
• Storage: Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
• Stability: Stable for at least 3 months from date of receipt under proper storage and handling conditions.
• Shipping: Dry Ice

Reference Data

• RefSeq: NP_066998
• Locus ID: 57817
• UniProt ID: P81172
• Cytogenetics: 19q13.12
• RefSeq Size: 430
• RefSeq ORF: 252
• Synonyms: HEPC; HFE2B; LEAP1; PLTR
• Summary: The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014]
• Protein Families: Secreted Protein, Transmembrane