LXR alpha (NR1H3) (NM_005693) Human Recombinant Protein

CAT#: TP323767

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Recombinant protein of human nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 1


 Product Datasheet for 'TP323767'

 Cited in 1 publication.

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USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 1
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 50.2 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Bioactivity Binding assay (Blue Native PAGE) (PMID: 27382175)
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_005684
Locus ID 10062
Refseq Size 1528
Cytogenetics 11p11.2
Refseq ORF 1341
Synonyms LXR-a; LXRA; RLD-1
Summary The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Protein Families Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
Protein Pathways PPAR signaling pathway

Citations (1)

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