LXR alpha (NR1H3) (NM_005693) Human Recombinant Protein
SKU
TP323767
Recombinant protein of human nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 1, 20 µg
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 50.2 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Bioactivity | Binding assay (Blue Native PAGE) (PMID: 27382175) |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_005684 |
| Locus ID | 10062 |
| UniProt ID | Q13133 |
| Cytogenetics | 11p11.2 |
| RefSeq Size | 1528 |
| RefSeq ORF | 1341 |
| Synonyms | LXR-a; LXRA; RLD-1 |
| Summary | The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Oct 2011 |
| Protein Categories | Intracellular Proteins, Transciption Factors |
| Protein Families | Druggable Genome, Nuclear Hormone Receptor, Transcription Factors |
| Protein Pathways | PPAR signaling pathway |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "LXR alpha" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH323767 | NR1H3 MS Standard C13 and N15-labeled recombinant protein (NP_005684) | 10 ug |
$3,360.00
|
|
| LC401738 | Lyophilized NR1H3 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY401738 | Transient overexpression lysate of nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 1 (as WB positive control) | 100 ug |
$665.00
|
|
Citations
Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex
Tian, Goldstein, Brown
PNAS (2016) 113 (29), 8182-7 DOI: 10.1073/pnas.1608987113
Tian, Goldstein, Brown
PNAS (2016) 113 (29), 8182-7 DOI: 10.1073/pnas.1608987113
Cited by 78
Showing 1-1 of 1 papers.
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in shipping.
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