Synapsin I (SYN1) (NM_006950) Human Recombinant Protein
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 73.9 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_008881 |
| Locus ID | 6853 |
| UniProt ID | P17600 |
| Cytogenetics | Xp11.3-p11.23 |
| RefSeq Size | 2248 |
| RefSeq ORF | 2115 |
| Synonyms | EPILX; MRX50; SYN1a; SYN1b; SYNI |
| Summary | This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. provided by RefSeq, Jul 2008 |
| Protein Categories | Intracellular Proteins, Nervous system Diseases |
Reviews
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| FAQs |
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Resources
| Recombinant Protein Resources |
Other "Synapsin I" proteins (5)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH321273 | SYN1 MS Standard C13 and N15-labeled recombinant protein (NP_008881) | 10 ug |
$3,360.00
|
|
| LC408828 | Lyophilized SYN1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC416298 | Lyophilized SYN1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY408828 | Transient overexpression lysate of synapsin I (SYN1), transcript variant Ib (as WB positive control) | 100 ug |
$665.00
|
|
| LY416298 | Transient overexpression lysate of synapsin I (SYN1), transcript variant Ia (as WB positive control) | 100 ug |
$665.00
|
|
Citations
Loss of intracellular ATP affects axoplasmic viscosity and pathological protein aggregation in mammalian neurons
Guillaud, Garanzini, Zakhia et al
Sci Adv (2025) 11 (17), eadq6077 DOI: 10.1126/sciadv.adq6077
Guillaud, Garanzini, Zakhia et al
Sci Adv (2025) 11 (17), eadq6077 DOI: 10.1126/sciadv.adq6077
Cited by 24
AI Summary: OriGene products contributed to this study by providing human recombinant full-length proteins, including SYN1 (#TP321273), SNCA (#PRO-393), SNCAA53T mutant (#PRO-159), Tau (#PRO-295), and Parkin (PARK2, #PRO-1840), which were used to investigate ATP-dependent protein condensation and aggregation relevant to neurodegenerative diseases.
Snippet: perature (5). Thus, we performed all our observation after 1 to 3 hours at 37°C in the absence of additional crowding agent. Human recombinant full length protein SYN1 (#TP321273) was purchased from OriGene Technologies Inc. Human recombinant full-length proteins SNCA (#pro-393), SNCAA53T mutant (#pro-159), microtubule-associated protein Tau (#pro-295), ubiquitin ligase Parkin (PARK2, #pro-1840),
Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease
Islam, Nolte, Jacob et al
Hum. Mol. Genet. (2016)
Islam, Nolte, Jacob et al
Hum. Mol. Genet. (2016)
Cited by 93
AI Summary: OriGene’s purified recombinant human synaptojanin-1 was used in in vitro kinase assays to demonstrate direct phosphorylation by mutant LRRK2, helping elucidate the molecular mechanisms underlying Parkinson’s disease in the study.
Snippet: In total, 300 ng of purified recombinant human synaptojanin-1 (Origene) was incubated with 1 nM recombinant GST-tagged human LRRK2 (970-2527;WT, R1441C or D1994A;Invitrogen) in 5 µl 10x kinase buffer (Cell Signalling Technology), 1 µl [γ- 33P]-ATP (1 µCi) in a final volume of 15 µl without incubation and incubated for 60 mins at 30°C or quenched directly
Showing 1-2 of 2 papers.
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