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Macrophage Scavenger Receptor I (MSR1) (NM_002445) Human Recombinant Protein

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SKU
TP312931
Recombinant protein of human macrophage scavenger receptor 1 (MSR1), transcript variant SR-AII, 20 µg
Size:
20 ug 1 mg 100 ug
  $867.00
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Frequently Bought Together (1)

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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
>RC212931 representing NM_002445
Red=Cloning site Green=Tags(s)

MEQWDHFHNQQEDTDSCSESVKFDARSMTALLPPNPKNSPSLQEKLKSFKAALIALYLLVFAVLIPLIGI
VAAQLLKWETKNCSVSSTNANDITQSLTGKGNDSEEEMRFQEVFMEHMSNMEKRIQHILDMEANLMDTEH
FQNFSMTTDQRFNDILLQLSTLFSSVQGHGNAIDEISKSLISLNTTLLDLQLNIENLNGKIQENTFKQQE
EISKLEERVYNVSAEIMAMKEEQVHLEQEIKGEVKVLNNITNDLRLKDWEHSQTLRNITLIQGPAGPPGE
KGDRGPTGESGPRGFPGPIGPPGLKGDRGAIGFPGSRGLPGYAGRPGNSGPKGQKGEKGSGNTLRPVQLT
DHIRAGPS

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag C-Myc/DDK
Predicted MW 39.4 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_002436
Locus ID 4481
UniProt ID P21757
Cytogenetics 8p22
RefSeq Size 2823
RefSeq ORF 1074
Synonyms CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI; SR-AII; SR-AIII; SRA
Summary This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. provided by RefSeq, Jul 2008
Protein Categories CD Markers, Intracellular Proteins, Membrane Proteins
Protein Families Druggable Genome, Transmembrane
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Other "Macrophage Scavenger Receptor I" proteins (10)
SKU Description Size Price
PH312931 MSR1 MS Standard C13 and N15-labeled recombinant protein (NP_002436) 10 ug
$3,360.00
PH323314 MSR1 MS Standard C13 and N15-labeled recombinant protein (NP_619730) 10 ug
$3,360.00
LC403366 Lyophilized MSR1 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC408527 Lyophilized MSR1 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC419319 Lyophilized MSR1 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY403366 Transient overexpression lysate of macrophage scavenger receptor 1 (MSR1), transcript variant SR-AI (as WB positive control) 100 ug
$436.00
LY408527 Transient overexpression lysate of macrophage scavenger receptor 1 (MSR1), transcript variant SR-AIII (as WB positive control) 100 ug
$436.00
LY419319 Transient overexpression lysate of macrophage scavenger receptor 1 (MSR1), transcript variant SR-AII (as WB positive control) 100 ug
$436.00
TP323314 Recombinant protein of human macrophage scavenger receptor 1 (MSR1), transcript variant SR-AIII, 20 µg 20 ug
$867.00
TP761290 Purified recombinant protein of Human macrophage scavenger receptor 1 (MSR1), transcript variant SR-AI, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug 50 ug
$270.00

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