RPE65 (NM_000329) Human Recombinant Protein

CAT#: TP310433

Recombinant protein of human retinal pigment epithelium-specific protein 65kDa (RPE65)

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 Product Datasheet for 'TP310433'

USD 438.00

USD 730.00


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Size
    • 20 ug

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Specifications

Product Data
Description Recombinant protein of human retinal pigment epithelium-specific protein 65kDa (RPE65)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence Recombinant protein was produced with TrueORF clone, RC210433. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag C-MYC/DDK
Predicted MW 60.8 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Reference Data
RefSeq NP_000320
Locus ID 6121
Refseq Size 2608
Cytogenetics 1p31.3
Refseq ORF 1599
Synonyms BCO3; LCA2; mRPE65; rd12; RP20; sRPE65
Summary This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq, Jul 2008].
Protein Families
Protein Pathways
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