RPE65 (NM_000329) Human Recombinant Protein

CAT#: TP310433

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Recombinant protein of human retinal pigment epithelium-specific protein 65kDa (RPE65)


 Product Datasheet for 'TP310433'

 Cited in 1 publication.

  View other "RPE65" proteins (3)

USD 748.00


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    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human retinal pigment epithelium-specific protein 65kDa (RPE65)
Species Human
Expression Host HEK293T
Expression cDNA Clone or AA Sequence Recombinant protein was produced with TrueORF clone, RC210433. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag C-Myc/DDK
Predicted MW 60.8 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_000320
Locus ID 6121
Refseq Size 2608
Cytogenetics 1p31.3
Refseq ORF 1599
Synonyms BCO3; LCA2; mRPE65; rd12; RP20; sRPE65
Summary The protein encoded by this gene is a component of the vitamin A visual cycle of the retina which supplies the 11-cis retinal chromophore of the photoreceptors opsin visual pigments. It is a member of the carotenoid cleavage oxygenase superfamily. All members of this superfamily are non-heme iron oxygenases with a seven-bladed propeller fold and oxidatively cleave carotenoid carbon:carbon double bonds. However, the protein encoded by this gene has acquired a divergent function that involves the concerted O-alkyl ester cleavage of its all-trans retinyl ester substrate and all-trans to 11-cis double bond isomerization of the retinyl moiety. As such, it performs the essential enzymatic isomerization step in the synthesis of 11-cis retinal. Mutations in this gene are associated with early-onset severe blinding disorders such as Leber congenital. [provided by RefSeq, Oct 2017]
Protein Families Druggable Genome
Protein Pathways Retinol metabolism

Citations (1)

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BOGO Free lysates
68 Mouse Clones
HUMAN PROREINS 101