NPTX2 (NM_002523) Human Recombinant Protein

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TP306713
Recombinant protein of human neuronal pentraxin II (NPTX2), 20 µg
  $737.00
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
>RC206713 representing NM_002523
Red=Cloning site Green=Tags(s)

MLALLAASVALAVAAGAQDSPAPGSRFVCTALPPEAVHAGCPLPAMPMQGGAQSPEEELRAAVLQLRETV
VQQKETLGAQREAIRELTGKLARCEGLAGGKARGAGATGKDTMGDLPRDPGHVVEQLSRSLQTLKDRLES
LEHQLRANVSNAGLPGDFREVLQQRLGELERQLLRKVAELEDEKSLLHNETSAHRQKTESTLNALLQRVT
ELERGNSAFKSPDAFKVSLPLRTNYLYGKIKKTLPELYAFTICLWLRSSASPGIGTPFSYAVPGQANEIV
LIEWGNNPIELLINDKVAQLPLFVSDGKWHHICVTWTTRDGMWEAFQDGEKLGTGENLAPWHPIKPGGVL
ILGQEQDTVGGRFDATQAFVGELSQFNIWDRVLRAQEIVNIANCSTNMPGNIIPWVDNNVDVFGGASKWP
VETCEERLLDL

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag C-Myc/DDK
Predicted MW 46.9 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_002514
Locus ID 4885
UniProt ID P47972
Cytogenetics 7q22.1
RefSeq Size 2746
RefSeq ORF 1293
Synonyms NARP; NP-II; NP2
Summary This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. provided by RefSeq, Feb 2009
Protein Categories Secreated Proteins
Protein Families Secreted Protein
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Other "NPTX2" proteins (5)
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PH306713 NPTX2 MS Standard C13 and N15-labeled recombinant protein (NP_002514) 10 ug
$3,360.00
LC419275 Lyophilized NPTX2 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
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LY419275 Transient overexpression lysate of neuronal pentraxin II (NPTX2) (as WB positive control) 100 ug
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TP701051 Purified recombinant protein of Human neuronal pentraxin II (NPTX2), with C-terminal His tag, secretory expressed in HEK293 cells, 50ug 50 ug
$900.00
TP710206 Purified recombinant protein of Human neuronal pentraxin II (NPTX2), full length, with C-terminal DDK tag, expressed in sf9, 20ug 20 ug
$540.00

file-alt Citations

Neuronal Pentraxin 2 is a regulator of clear cell renal cell carcinoma malignancy through activation of the AMPA-selective glutamate receptor 4
Von Roemeling, Radisky, Marlow et al
Cancer Res. (2014)
AI Summary: In this study, OriGene’s human recombinant NPTX2 (R-NPTX2) protein was used to investigate the role of NPTX2 in promoting tumor cell viability and migration in clear cell renal cell carcinoma.
Snippet: Page 5. 5 examined via DNA sequencing and multiplex ligation dependent probe amplification, respectively. Human recombinant NPTX2 (R-NPTX2) generated in HEK293 cells was purchased from OriGene. CFM-2 was purchased from Tocris Bioscience. Lentivirus ... Cite SaveSaving
Showing 1-1 of 1 papers.
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