PMS2 (NM_000535) Human Mass Spec Standard
$3,360.00
3 Weeks*
Specifications
| Product Data | |
| Tag | C-Myc/DDK |
|---|---|
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | RC210880 |
| Predicted MW | 95.8 kDa |
| Protein Sequence | |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Labeling Method | Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| Storage | Store at -80°C. Avoid repeated freeze-thaw cycles. |
| Stability | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_000526 |
| RefSeq Size | 2851 |
| RefSeq ORF | 2586 |
| Synonyms | HNPCC4; MLH4; MMRCS4; PMS2CL; PMSL2 |
| Locus ID | 5395 |
| UniProt ID | P54278 |
| Cytogenetics | 7p22.1 |
| Summary | The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. provided by RefSeq, Apr 2016 |
| Protein Families | Druggable Genome |
| Protein Pathways | Mismatch repair |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "PMS2" proteins (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| LC424658 | Lyophilized PMS2 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY424658 | Transient overexpression lysate of PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2), transcript variant 1 (as WB positive control) | 100 ug |
$436.00
|
|
| TP310880 | Recombinant protein of human PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2), transcript variant 1, 20 µg | 20 ug |
$737.00
|
|
| TP762401 | Purified recombinant protein of Human PMS2 postmeiotic segregation increased 2 (S. cerevisiae) (PMS2), transcript variant 1, Ala626-Asn708, with N-terminal His tag, expressed in E.coli, 50ug | 50 ug |
$260.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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