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Rab5 (RAB5A) (NM_004162) Human Mass Spec Standard

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SKU
PH303873
RAB5A MS Standard C13 and N15-labeled recombinant protein (NP_004153)
Size:
10 ug
  $3,360.00
In Stock*
Bulk/Customize

Frequently Bought Together (2)

TA812808 RAB5A mouse monoclonal antibody,clone OTI6D9 100 ul
$447.00
LY401339 Transient overexpression lysate of RAB5A, member RAS oncogene family (RAB5A) (as WB positive control) 100 ug
$436.00

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Specifications
Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC203873
Predicted MW 23.7 kDa
Protein Sequence
Protein Sequence
>RC203873 protein sequence
Red=Cloning site Green=Tags(s)

MASRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVK
FEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLANK
RAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVDLTEPTQPTRN
QCCSN

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_004153
RefSeq Size 2548
RefSeq ORF 645
Synonyms RAB5
Locus ID 5868
UniProt ID P20339
Cytogenetics 3p24.3
Summary The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).UniProtKB/Swiss-Prot Function
Protein Families Druggable Genome
Protein Pathways Amyotrophic lateral sclerosis (ALS), Endocytosis
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Other "Rab5" proteins (3)
SKU Description Size Price
LC401339 Lyophilized RAB5A HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY401339 Transient overexpression lysate of RAB5A, member RAS oncogene family (RAB5A) (as WB positive control) 100 ug
$436.00
TP303873 Recombinant protein of human RAB5A, member RAS oncogene family (RAB5A), 20 µg 20 ug
$867.00

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