FBXL11 (KDM2A) (NM_012308) Human Tagged ORF Clone Lentiviral Particle

SKU RC223440L3V

Lenti ORF particles, KDM2A (Myc-DDK tagged) - Human lysine (K)-specific demethylase 2A (KDM2A), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: FBXL11
• Synonyms: CXXC8; FBL7; FBL11; FBXL11; JHDM1A; LILINA
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC223440).
• ACCN: NM_012308
• ORF Size: 3486 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_012308.1
• RefSeq Size: 6210 bp
• RefSeq ORF: 3489 bp
• Locus ID: 22992
• UniProt ID: Q9Y2K7
• Cytogenetics: 11q13.2
• Domains: F-box, JmjC, LRR_CC, PHD, zf-CXXC
• Protein Families: Druggable Genome, Transcription Factors
• MW: 132.6 kDa
• Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]