Glutaredoxin 1 (GLRX) (NM_002064) Human Tagged ORF Clone Lentiviral Particle

SKU RC219385L2V

Lenti ORF particles, GLRX (mGFP-tagged) - Human glutaredoxin (thioltransferase) (GLRX), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: Glutaredoxin 1
• Synonyms: GRX; GRX1
• Vector: pLenti-C-mGFP
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC219385).
• ACCN: NM_002064
• ORF Size: 318 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_002064.1
• RefSeq Size: 1328 bp
• RefSeq ORF: 321 bp
• Locus ID: 2745
• UniProt ID: P35754
• Cytogenetics: 5q15
• Domains: glutaredoxin
• Protein Families: Druggable Genome
• MW: 11.6 kDa
• Summary: This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]