PPIL5 (LRR1) (NM_203467) Human Tagged ORF Clone Lentiviral Particle

SKU RC219090L3V

Lenti ORF particles, LRR1 (Myc-DDK tagged) - Human leucine rich repeat protein 1 (LRR1), transcript variant 3, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: PPIL5
• Synonyms: 4-1BBLRR; LRR-1; PPIL5
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC219090).
• ACCN: NM_203467
• ORF Size: 438 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_203467.1, NP_982292.1
• RefSeq Size: 1049 bp
• RefSeq ORF: 441 bp
• Locus ID: 122769
• UniProt ID: Q96L50
• Cytogenetics: 14q21.3
• Protein Families: Druggable Genome
• MW: 16.8 kDa
• Summary: The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]