CLACP (COL25A1) (NM_198721) Human Tagged ORF Clone Lentiviral Particle

SKU RC217472L3V

Lenti ORF particles, COL25A1 (Myc-DDK tagged) - Human collagen, type XXV, alpha 1 (COL25A1), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: CLACP
• Synonyms: AMY; CFEOM5; CLAC; CLAC-P; CLACP
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC217472).
• ACCN: NM_198721
• ORF Size: 1962 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_198721.1
• RefSeq Size: 2607 bp
• RefSeq ORF: 1965 bp
• Locus ID: 84570
• UniProt ID: Q9BXS0
• Cytogenetics: 4q25
• Protein Families: Transmembrane
• MW: 64.6 kDa
• Summary: This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]