Prostaglandin D Synthase (PTGDS) (NM_000954) Human Tagged ORF Clone Lentiviral Particle

SKU RC216795L1V

Lenti ORF particles, PTGDS (Myc-DDK tagged) - Human prostaglandin D2 synthase 21kDa (brain) (PTGDS), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: Prostaglandin D Synthase
• Synonyms: L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2
• Vector: pLenti-C-Myc-DDK
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC216795).
• ACCN: NM_000954
• ORF Size: 570 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_000954.5, NP_000945.3
• RefSeq Size: 837 bp
• RefSeq ORF: 573 bp
• Locus ID: 5730
• UniProt ID: P41222
• Cytogenetics: 9q34.3
• Domains: lipocalin
• Protein Pathways: Arachidonic acid metabolism, Metabolic pathways
• MW: 20.8 kDa
• Summary: The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]