APLP1 (NM_005166) Human Tagged ORF Clone Lentiviral Particle

SKU RC215282L3V

Lenti ORF particles, APLP1 (Myc-DDK tagged) - Human amyloid beta (A4) precursor-like protein 1 (APLP1), transcript variant 2, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: APLP1
• Synonyms: APLP
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC215282).
• ACCN: NM_005166
• ORF Size: 1950 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_005166.3
• RefSeq Size: 2447 bp
• RefSeq ORF: 1953 bp
• Locus ID: 333
• UniProt ID: P51693
• Cytogenetics: 19q13.12
• Domains: A4_EXTRA
• Protein Families: Druggable Genome, Transmembrane
• MW: 72.18 kDa
• Summary: This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]