KCNQ2 (NM_172107) Human Tagged ORF Clone Lentiviral Particle

SKU RC212932L1V

Lenti ORF particles, KCNQ2 (Myc-DDK tagged) - Human potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: KCNQ2
• Synonyms: BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11; KV7.2
• Vector: pLenti-C-Myc-DDK
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC212932).
• ACCN: NM_172107
• ORF Size: 2616 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_172107.2
• RefSeq Size: 3251 bp
• RefSeq ORF: 2619 bp
• Locus ID: 3785
• UniProt ID: O43526
• Cytogenetics: 20q13.33
• Protein Families: Druggable Genome, Ion Channels: Potassium, Transmembrane
• MW: 95.7 kDa
• Summary: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]