GCN2 (EIF2AK4) (NM_001013703) Human Tagged ORF Clone Lentiviral Particle

SKU RC212459L3V

Lenti ORF particles, EIF2AK4 (Myc-DDK tagged) - Human eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: GCN2
• Synonyms: GCN2; PVOD2
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC212459).
• ACCN: NM_001013703
• ORF Size: 4947 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_001013703.2, NP_001013725.2
• RefSeq Size: 5532 bp
• RefSeq ORF: 4950 bp
• Locus ID: 440275
• UniProt ID: Q9P2K8
• Cytogenetics: 15q15.1
• Protein Families: Druggable Genome, Protein Kinase
• MW: 187.4 kDa
• Summary: This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]