TRIM50 (NM_178125) Human Tagged ORF Clone Lentiviral Particle

SKU RC211340L1V

Lenti ORF particles, TRIM50 (Myc-DDK tagged) - Human tripartite motif containing 50 (TRIM50), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: TRIM50
• Synonyms: TRIM50A
• Vector: pLenti-C-Myc-DDK
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC211340).
• ACCN: NM_178125
• ORF Size: 1461 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_178125.2, NP_835226.2
• RefSeq Size: 2050 bp
• RefSeq ORF: 1464 bp
• Locus ID: 135892
• UniProt ID: Q86XT4
• Cytogenetics: 7q11.23
• Protein Families: Druggable Genome
• MW: 54.7 kDa
• Summary: E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction.[UniProtKB/Swiss-Prot Function]